Vascular endothelial growth factor serum level as a prognostic and diagnostic marker for colorectal cancer

Ahmed Ali Nasar

doi:10.66632/eei-2026-31

Authors

Ahmed Ali Nasar Department of Civil Engineering, Higher Technological Institute, 10th of Ramadan City, Egypt Author

DOI:

https://doi.org/10.66632/eei-2026-31

Keywords:

Rectal Carcinoma, VEGF, CEA, CA19-9

Abstract

Although early detection is essential, radical surgery remains the main treatment for colorectal cancer, a major cause of cancer-related fatalities. The blood markers used in clinical practice for colorectal cancer (CA19-9) are carbohydrate antigen and carci-noemberyonic antigen (CEA). Both are only used for surveillance and as prognostic markers for disease-free survival because of their limited sensitivity and specificity. They are not used for screening or diagnosis. Therefore, there is an urgent need for a serum marker that facilitates early detection. Since angiogenesis is essential to the de-velopment and spread of cancers, targeting it has been shown to be an effective an-ti-tumor therapy. Vascular endothelial growth factor (VEGF), whose serum quantity has been connected to a variety of human malignancies, is one of the primary inducers of angiogenesis and may be used as a prognostic marker for solid tumors. Examining VEGF expression in patients with colorectal cancer (CRC) and comparing the findings to the patients' clinicopathologic features was the aim of this study. 68 patients and 10 healthy controls had their serum levels of CEA and CA19-9 compared to their VEGF levels. The results showed that higher serum levels of VEGF in CRC patients were sig-nificantly correlated with levels of CEA and CA19-9. In conclusion, determining VEGF serum levels can aid in the diagnosis of colorectal cancer (CRC) patients and open the door to VEGF inhibitor-based tailored treatment of CRC patients.

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